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Predominant white matter microstructural changes over gray matter in tinnitus brain.

Qianhui Xu1, Tingting Chai2, Jun Yao3

  • 1Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Neuroimage
|April 25, 2025
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Summary
This summary is machine-generated.

Tinnitus patients exhibit white matter microstructural changes, including fiber disruption and altered connectivity, impacting cognitive functions. These brain alterations, not gray matter changes, correlate with neuropsychological performance deficits in tinnitus.

Keywords:
MicrostructuralMulti-shellNeuropsychologicalTinnitusTopological properties

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Imaging

Background:

  • Tinnitus is a complex auditory disorder potentially linked to brain structural and functional alterations.
  • Understanding white matter and gray matter microstructural changes in tinnitus is crucial for explaining associated cognitive deficits.

Purpose of the Study:

  • To investigate white matter and gray matter microstructural differences in tinnitus patients compared to healthy controls.
  • To examine the relationship between observed brain microstructural changes and neuropsychological performance in tinnitus.

Main Methods:

  • A cross-sectional study utilizing multi-shell Diffusion Weighted Imaging (DWI) and advanced modeling (DTI, NODDI) in 48 tinnitus patients and 48 controls.
  • Tract-Based Spatial Statistics (TBSS) and Gray Matter-Based Spatial Statistics (GBSS) were employed for microstructural analysis.
  • Neuropsychological assessments were conducted, and correlations between brain metrics and cognitive performance were analyzed.

Main Results:

  • Tinnitus patients showed white matter abnormalities, including decreased axial diffusivity and increased orientation dispersion in specific tracts (e.g., forceps minor).
  • Reduced white matter connectivity strength and network efficiency were observed in tinnitus patients.
  • No significant gray matter microstructural changes were detected; orientation dispersion mediated the link between tinnitus and cognitive test performance.

Conclusions:

  • White matter fiber disruption and altered internal connectivity are more prominent in tinnitus than gray matter changes.
  • These white matter microstructural alterations are associated with cognitive function changes in individuals with tinnitus.