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Updated: May 10, 2025

Extraction and Analysis of Taiwanese Green Propolis

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

Alginate-based microcapsules loaded with Brazilian green propolis decrease reactive oxygen species production, reduce

Marcelo Franchin¹, Ana Sofia Martelli Chaib Saliba², Anderson Dos Santos Ramos³

¹Bioactivity and Applications Laboratory, Department of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland; Graduate Program in Biological Sciences, Federal University of Alfenas (Unifal-MG), Alfenas, Brazil.

International Journal of Biological Macromolecules

|April 25, 2025

Summary

This summary is machine-generated.

Alginate microcapsules loaded with Brazilian green propolis extract (EEGP-MC) effectively reduced inflammation and protected the colon in experimental colitis. This innovative delivery system shows promise for managing inflammatory conditions.

Keywords:

Alginate Antioxidant Cytokines Galleria mellonella Inflammation Macrophage Microcapsules Propolis

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Area of Science:

Biomaterials Science
Pharmacology
Gastroenterology

Background:

Ulcerative colitis is characterized by intestinal inflammation, with current treatments facing limitations in efficacy and safety.
Brazilian green propolis possesses anti-inflammatory properties, offering potential for managing inflammatory conditions.
Controlled-release technologies can enhance the delivery and efficacy of bioactive compounds.

Purpose of the Study:

To develop alginate-based microcapsules loaded with ethanolic extract of green propolis (EEGP-MC).
To evaluate the anti-inflammatory effects of EEGP-MC on cytokines, reactive oxygen species (ROS), and experimental colitis.
To assess the safety and therapeutic potential of EEGP-MC for chronic inflammation management.

Main Methods:

Fabrication of alginate microcapsules encapsulating ethanolic extract of green propolis (EEGP).
In vitro release studies of phenolic compounds and Artepillin C from microcapsules.
Assessment of EEGP-MC effects on TNF-α, IL-6, and ROS production in THP-1 cell cultures.
In vivo evaluation of EEGP-MC in an experimental colitis model, assessing colonic lesions and inflammatory markers.

Main Results:

EEGP-MC demonstrated controlled release of phenolic compounds and Artepillin C in the intestinal phase.
EEGP-MC pretreatment significantly reduced TNF-α, IL-6 levels, and ROS production in cell cultures.
Oral administration of EEGP-MC markedly reduced colonic lesions (86.1%) in experimental colitis compared to EEGP alone (54.9%).
EEGP-MC treatment suppressed key inflammatory cytokines (TNF-α, IL-6, IL-1β) in intestinal tissue.

Conclusions:

EEGP-MC represents an effective controlled-release system for Brazilian green propolis.
EEGP-MC exhibits significant anti-inflammatory and protective effects in experimental colitis.
This technology holds promise for applications in the food and pharmaceutical industries for managing chronic inflammation.