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An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

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Cobra venom keratoconjunctivitis.

Rita Sofia Glazer¹, Jane Durcan², Susan MacDonald³

¹Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.

BMJ Case Reports

|April 25, 2025

Summary

This summary is machine-generated.

Cobra venom can cause severe eye injury, leading to pain and vision loss. Prompt irrigation and antibiotic treatment effectively managed this case of cobra venom keratoconjunctivitis, restoring the patient's vision.

Keywords:

Ophthalmology Public health

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Area of Science:

Ophthalmology
Toxicology
Herpetology

Background:

Snake envenomation presents a significant global health challenge.
Ocular injuries from spitting cobras, known as cobra venom keratoconjunctivitis, result from venom sprayed into the eyes.

Purpose of the Study:

To report a case of cobra venom keratoconjunctivitis.
To describe the clinical presentation and management of this specific ocular injury.

Main Methods:

A patient presenting with acute eye pain, photophobia, and decreased vision after cobra venom exposure was treated.
Initial management included topical anesthesia, extensive irrigation with lactated Ringer's solution, and antibiotic ointment.
The affected eye was patched for 24 hours, with subsequent antibiotic application and follow-up.

Main Results:

The patient experienced significant pain reduction within 24 hours of treatment.
While initial vision remained blurred, it gradually improved.
Full visual recovery to baseline levels was achieved several weeks post-injury.

Conclusions:

Cobra venom keratoconjunctivitis requires immediate and thorough irrigation.
Prompt and appropriate ophthalmic care, including antibiotics, can lead to favorable visual outcomes.
This case highlights the importance of recognizing and managing venomous snake eye-spitting injuries.