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Related Experiment Videos

Brain Network Abnormalities in Obsessive-Compulsive Disorder: Insights from Edge Functional Connectivity Analysis.

Yongwang Xu1,2, Hongfei Liu3, Haiyan Liu1,2

  • 1Center for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China.

Behavioral Sciences (Basel, Switzerland)
|April 26, 2025
PubMed
Summary

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Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
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Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
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This summary is machine-generated.

Obsessive-compulsive disorder (OCD) is linked to altered brain network entropy. Patients with OCD showed reduced entropy in the dorsal attention network (DAN) and increased entropy in the control network (CN) and default mode network (DMN).

Area of Science:

  • Neuroscience
  • Psychiatry
  • Computational Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) is associated with functional differences in key brain networks like the dorsal attention network (DAN), control network (CN), and default mode network (DMN).
  • The exact nature of these functional differences and their neurobiological underpinnings in OCD remain incompletely understood.

Purpose of the Study:

  • To investigate and validate functional connectivity (FC) alterations in brain networks within individuals with OCD.
  • To employ a novel edge functional connectivity (eFC) approach for a more refined analysis of brain network interactions in OCD.
  • To explore network entropy as a potential biomarker for OCD.

Main Methods:

  • Collected resting-state functional magnetic resonance imaging (fMRI) data during movie watching from 44 patients with OCD and 33 healthy controls (HCs).
Keywords:
edge functional connectivitynetwork entropyobsessive–compulsive disorder

Related Experiment Videos

  • Utilized a novel edge functional connectivity (eFC) approach for detailed network interaction analysis.
  • Applied a two-sample t test to compare network entropy differences in the DAN, CN, and DMN between groups, controlling for confounding variables.

    • Main Results:

    • Significant differences in network entropy were observed between the OCD and HC groups.
    • Patients with OCD exhibited significantly reduced entropy in the DAN compared to HCs.
    • Conversely, patients with OCD showed significantly increased entropy in the CN and DMN relative to HCs.

    Conclusions:

    • The observed alterations in network entropy (decreased in DAN, increased in CN and DMN) may underlie core OCD symptoms like attention deficits, impaired cognitive control, and self-referential thinking.
    • Network entropy emerges as a potentially valuable biomarker for OCD, offering insights into its neurobiological mechanisms.
    • Future research should correlate these network changes with OCD symptom severity and explore their therapeutic implications.