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Shared Genomic Features Between Lung Adenocarcinoma and Type 2 Diabetes: A Bioinformatics Study
Nuerbiye Nueraihemaiti1,2,3,4, Dilihuma Dilimulati1,2,3,4, Alhar Baishan1,2,3,4
1Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Biology
|April 26, 2025
Summary
This study identifies common genomic mechanisms in lung adenocarcinoma and type 2 diabetes, highlighting immune response and TGF-β signaling. Key biomarkers ATR, RFC4, and MCM2 show potential for treating these related conditions.
Area of Science:
- Oncology
- Endocrinology
- Genomics
Background:
- Lung adenocarcinoma (LUAD) is a prevalent non-small cell lung cancer subtype.
- Type 2 diabetes (T2DM) significantly increases LUAD risk.
- Shared genomic characteristics between LUAD and T2DM warrant investigation.
Purpose of the Study:
- To identify common genomic features between LUAD and T2DM.
- To explore the role of immune cell infiltration and signaling pathways.
- To discover potential biomarkers for comorbid LUAD and T2DM.
Main Methods:
- Utilized bioinformatics analysis on public datasets (GSE40791, GSE25724, GSE10072, GSE71416).
- Identified differentially expressed genes (DEGs) and performed Gene Ontology (GO) and KEGG pathway enrichment analysis.
- Constructed protein-protein interaction networks and identified hub genes (e.g., ATR, RFC4, MCM2).
Main Results:
- Identified 748 DEGs common to LUAD and T2DM.
- Observed significant immune cell infiltration (e.g., CD8 T cells, macrophages) and enrichment in immune-related pathways, including TGF-β signaling.
- Pinpointed seven hub genes, with ATR, RFC4, and MCM2 identified as pivotal, alongside associated miRNAs and transcription factors (SP1, KDM5A).
Conclusions:
- Elucidated shared immune response and TGF-β signaling pathway mechanisms in LUAD and T2DM.
- Identified ATR, RFC4, and MCM2 as potential biomarkers and therapeutic targets for the comorbidity of LUAD and T2DM.
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