Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

242
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
242

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sodium carboxymethylcellulose-sodium caseinate complex hydrocolloid enhances the oil barrier properties of batter-coated deep-fried pork.

Journal of the science of food and agriculture·2026
Same author

Real-time nanomolar vitamin monitoring in sweat using an electrochemical skin-attached device.

Nature communications·2026
Same author

Impact of Co-Fermentation with <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> IU100 and Type III Resistant Starch on the Aroma Profile of Fermented Milk.

Foods (Basel, Switzerland)·2026
Same author

Characterization of Milk Fat Globule Membrane Phospholipids in Colostrum of <i>Holstein cows</i>, <i>Yaks</i> and <i>Buffaloes</i> as Well as in <i>Yak</i> Colostrum and Mature Milk.

Foods (Basel, Switzerland)·2026
Same author

Subcellular Localization Dictates Therapeutic Function: Spatially Targeted Delivery of Amuc_1100 by Engineered <i>Lacticaseibacillus paracasei</i> L9 Enhances Intestinal Barrier in Colitis.

Nutrients·2026
Same author

Rate Comparison of the Maillard Reaction Between Milk Proteins and Human Milk Oligosaccharide.

Journal of food science·2025

Related Experiment Video

Updated: May 10, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

11.7K

Preparation and Characterization of Vitamin D3-Based Binary Amorphous Systems.

Xiaoshuo Zhao1, Xuemei Wang1, Qiuyang Wu1

  • 1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Foods (Basel, Switzerland)
|April 26, 2025
PubMed
Summary

Vitamin D3 (VD3) solubility is enhanced 80-fold using L-arginine (ARG) in a novel amorphous system. This breakthrough improves VD3 absorption for better oral supplements and functional foods.

Keywords:
L-arginineamorphoussolubilityvitamin D3

More Related Videos

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.4K
Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

7.1K

Related Experiment Videos

Last Updated: May 10, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

11.7K
Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.4K
Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

7.1K

Area of Science:

  • Nutritional Science
  • Pharmaceutical Science
  • Materials Science

Background:

  • Vitamin D3 (VD3) is vital for bone health and immune function but suffers from poor oral absorption due to low aqueous solubility.
  • VD3 deficiency is a global health concern, necessitating improved delivery systems for supplements and functional foods.
  • Developing effective oral formulations for poorly soluble compounds like VD3 remains a significant challenge.

Purpose of the Study:

  • To develop a novel formulation strategy to enhance the aqueous solubility and dissolution of Vitamin D3 (VD3).
  • To investigate the potential of binary amorphous systems for improving VD3 bioavailability.
  • To explore the molecular interactions and physical characteristics of VD3-L-arginine (ARG) binary systems.

Main Methods:

  • Preparation of 11 binary systems using solvent evaporation, focusing on VD3 and L-arginine (ARG).
  • Characterization of the binary amorphous system, including solubility, dissolution behavior, and morphology.
  • Analysis of molecular interactions between VD3 and ARG using techniques to identify hydrogen bonding sites.

Main Results:

  • The VD3-ARG binary amorphous system demonstrated an 80-fold increase in VD3 solubility compared to crystalline VD3.
  • Confirmed amorphization and observed specific morphology of the VD3-ARG system.
  • Identified hydrogen bonding as the primary interaction, with three specific bonding sites between VD3 and ARG.
  • Observed significantly enhanced dissolution behavior and a higher, sustained saturation level for VD3 in the VD3-ARG system.

Conclusions:

  • The VD3-ARG binary amorphous system represents a promising formulation strategy for enhancing VD3 solubility and dissolution.
  • This approach can significantly improve oral absorption, paving the way for more effective VD3 supplements and functional foods.
  • The study highlights the potential of amorphous binary systems in overcoming bioavailability challenges for poorly soluble nutrients.