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Asprosin and Neuregulin 4 in Obesity in Children
Ramazan Dulkadir1, Gamze Turna Saltoglu2, Ali Gunes1
1Department of Pediatrics, Faculty of Medicine, Kirsehir Ahi Evran University, Kirsehir 40100, Turkey.
Medicina (Kaunas, Lithuania)
|April 26, 2025
Summary
Pediatric obesity research found neuregulin 4 levels higher in normal-weight children, while asprosin levels were similar. Further studies are needed to understand these adipokines
Area of Science:
- Pediatric Endocrinology
- Nutritional Science
- Obesity Research
Background:
- Childhood obesity is a significant global nutritional challenge.
- Adipokines like asprosin and neuregulin 4 are emerging factors in metabolic health.
- Understanding novel adipokine roles in pediatric obesity is crucial.
Purpose of the Study:
- To investigate serum concentrations of asprosin and neuregulin 4 in pediatric obesity.
- To correlate these adipokines with obesity-related anthropometric and biochemical markers.
- To compare adipokine levels between obese children and normal-weight controls.
Main Methods:
- Cross-sectional study comparing 40 obese children with 40 normal-weight children.
- Serum levels of asprosin and neuregulin 4 were measured.
- Anthropometric, biochemical (including HOMA-IR), and hormonal parameters were assessed.
Main Results:
- Asprosin serum levels did not differ significantly between obese and normal-weight children.
- Neuregulin 4 and HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) were significantly elevated in the obese group (p < 0.05).
- Neuregulin 4 levels were found to be higher in normal-weight children compared to obese children.
Conclusions:
- Neuregulin 4 may play a complex role in pediatric obesity, with lower levels observed in obese children.
- Asprosin does not appear to be a differentiating factor in pediatric obesity in this cohort.
- Further research is essential to elucidate the precise roles of asprosin and neuregulin 4 in childhood obesity.
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