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Trauma Burden Affected People with Multiple Sclerosis During SARS-CoV-2 Pandemic.

Felicita Heidler1, Michael Hecker2, Niklas Frahm2

  • 1Department of Neurology, Ecumenic Hainich Hospital gGmbH, 99974 Mühlhausen, Germany.

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The COVID-19 pandemic triggered probable post-traumatic stress disorder (PTSD) in 8.1% of people with multiple sclerosis (pwMS), particularly those with pre-existing anxiety and depression. Understanding patient characteristics is crucial for targeted support and clear communication regarding health interventions.

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SARS-CoV-2anxietydepressionmultimorbiditymultiple sclerosispandemicpolypharmacytraumavaccination willingness

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Area of Science:

  • Neurology
  • Psychiatry
  • Epidemiology

Background:

  • The SARS-CoV-2 pandemic presented unique stressors for individuals with multiple sclerosis (pwMS).
  • The psychological impact, including trauma and probable post-traumatic stress disorder (PTSD), in pwMS during the pandemic remains underexplored.
  • Identifying patient characteristics associated with trauma is essential for providing adequate support.

Purpose of the Study:

  • To determine the prevalence and evolution of probable PTSD in pwMS during the SARS-CoV-2 pandemic.
  • To identify sociodemographic, clinical, and psychological factors associated with probable PTSD in pwMS.
  • To inform supportive care strategies and communication during public health crises.

Main Methods:

  • A bicentric prospective cohort study assessed 149 pwMS for probable PTSD using an adapted Trauma Screening Questionnaire (TSQ) before and after vaccine approval in Germany.
  • Comparison between pwMS with probable PTSD (TSQ sum score ≥ 6) and those without (TSQ sum score < 6).
  • Assessment included sociodemographic data, MS-specific characteristics, polypharmacy, comorbidities, anxiety/depression levels, personality traits, burden, and vaccination willingness.

Main Results:

  • 8.1% of pwMS exhibited probable PTSD.
  • Patients with probable PTSD had significantly higher rates of pre-pandemic anxiety and depression.
  • Probable PTSD was linked to higher neuroticism and harm avoidance, lower conscientiousness, cooperativeness, and self-directedness, and greater mental/physical/social burden during the pandemic.

Conclusions:

  • Targeted medical and social support services are necessary for individuals experiencing significant stress or trauma.
  • Educational and vaccination strategies require clear communication that acknowledges individual risk factors and addresses concerns with evidence-based information.
  • Recognizing psychological vulnerabilities in pwMS is key to effective public health interventions.