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Enhancing Boron Neutron Capture Therapy (BNCT) with Materials Based on COSAN-Functionalized Nanoparticles.

Albert Ferrer-Ugalde1, Amanda Muñoz-Juan1, Anna Laromaine1

  • 1Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus U.A.B., 08193 Bellaterra, Barcelona, Spain.

Pharmaceuticals (Basel, Switzerland)
|April 26, 2025
PubMed
Summary

New nanoparticles (NP@I-COSAN) effectively deliver boron for Boron Neutron Capture Therapy (BNCT), enhancing tumor cell targeting and apoptosis with low toxicity.

Keywords:
BNCTC. elegansboron clustersmetallacarboranes

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Area of Science:

  • Nanomedicine
  • Biotechnology
  • Radiotherapy

Background:

  • Boron Neutron Capture Therapy (BNCT) requires efficient boron delivery systems for targeting malignant cells.
  • Current boron delivery agents face challenges in achieving adequate tumor cell accumulation.
  • Developing novel carriers is crucial for advancing BNCT efficacy.

Purpose of the Study:

  • To synthesize and characterize COSAN-functionalized nanoparticles (NP@I-COSAN) as a boron delivery system for BNCT.
  • To evaluate the biocompatibility, cellular uptake, and therapeutic potential of NP@I-COSAN.
  • To compare NP@I-COSAN's performance against traditional boron agents.

Main Methods:

  • Hybrid nanoparticles (NP@I-COSAN) synthesized by conjugating I-COSAN to acrylic polymer nanoparticles.
  • Characterization using FTIR, TGA, UV-Vis, TEM/EDX; cellular uptake and boron quantification via ICP-MS.
  • Cytotoxicity assays in HeLa cells and *C. elegans*; in vitro BNCT proof-of-concept assay.

Main Results:

  • NP@I-COSAN exhibited low cytotoxicity and efficient cellular internalization.
  • Stable boron retention was observed, comparable to established boron agents like f-BPA.
  • In vitro BNCT assays demonstrated NP@I-COSAN's efficacy in inducing tumor cell apoptosis at lower concentrations.

Conclusions:

  • NP@I-COSAN shows significant potential as an effective boron delivery system for BNCT.
  • This nanoparticle strategy can enhance boron accumulation in tumor cells.
  • NP@I-COSAN offers a promising approach to improve BNCT treatment outcomes.