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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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T1 mapping and major cardiovascular events in non-ischaemic dilated cardiomyopathy: a systematic review and

Federico Marchini1, Beatrice Dal Passo1, Gianluca Campo1

  • 1Cardiovascular Institute, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.

ESC Heart Failure
|April 26, 2025
PubMed

Insights

Native T1 mapping and extracellular volume (ECV) predict major adverse cardiovascular events (MACE) in non-ischaemic dilated cardiomyopathy (NIDCM) patients. These cardiac MRI techniques identify patients at higher risk for heart failure and arrhythmias.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Non-ischaemic dilated cardiomyopathy (NIDCM) is a significant cause of heart failure.
  • Accurate risk stratification is crucial for managing NIDCM patients.
  • T1 mapping techniques offer novel insights into myocardial tissue characterization.

Purpose of the Study:

  • To evaluate the prognostic value of T1 mapping and extracellular volume (ECV) in predicting major adverse cardiovascular events (MACE) in NIDCM.
  • To conduct a meta-analysis of existing studies to consolidate evidence.

Main Methods:

  • A meta-analysis of 12 observational studies involving 4025 NIDCM patients.
  • Analysis of native T1 mapping and ECV for prediction of MACE, heart failure, and arrhythmic events.
  • Random effects model with generic inverse variance for pooled hazard ratios (HR) and mean differences.

Main Results:

  • Native T1 mapping showed a pooled HR of 1.07 (95% CI 1.04-1.09) for MACE.
  • ECV demonstrated a pooled HR of 1.37 (95% CI 1.29-1.44) for MACE.
  • Both T1 mapping and ECV were significantly associated with increased risk of MACE, heart failure, and arrhythmic events.

Conclusions:

  • Native T1 mapping and ECV are valuable prognostic markers in NIDCM.
  • These cardiac MRI techniques can identify patients at elevated risk for adverse cardiovascular outcomes.
  • Integration of T1 mapping and ECV into clinical practice may improve NIDCM patient management.
Abstract

Keywords:
CMRCardiovascular magnetic resonanceECVMACENative T1 mappingNon‐ischaemic dilated cardiomyopathy

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