Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing Inclusion Complexation Mechanisms in Polycyclodextrin Nanofibers via ESR Spectroscopy.

The journal of physical chemistry. B·2026
Same author

Amyloid fibrils from food proteins as functional delivery systems for bioactive compounds.

Advances in colloid and interface science·2026
Same author

Development of food protein amyloid fibrils co-formulated with polysaccharides, polyphenols, and proteins: A review.

International journal of biological macromolecules·2026
Same author

Room-Temperature Conformally Coated Cotton Fabrics for Integrated Textile Sensors.

ACS applied materials & interfaces·2026
Same author

Advanced processes for engineering food protein amyloid fibrils: Molecular mechanisms, processing parameters, and structure-function relationships.

Advances in colloid and interface science·2026
Same author

Highly efficient and selective removal of cationic and anionic dyes from aqueous solutions by poly-cyclodextrin nanofibrous membranes.

Carbohydrate polymers·2026

Related Experiment Video

Updated: Jul 2, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.6K

Recent developments in nanofiber-based fast-disintegrating drug delivery systems.

Fuat Topuz1, Tamer Uyar2

  • 1Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Sariyer, Istanbul, Turkey.

Expert Opinion on Drug Delivery
|April 26, 2025
PubMed
Summary

Fast-disintegrating electrospun fibers offer innovative oral drug delivery. Recent advancements focus on fiber composition and structure to enhance drug release and bioavailability.

Keywords:
Electrospun fiberscyclodextrinsdrug deliveryfast-disintegrating fibershydrophilic polymerspullulan

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.7K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

838

Related Experiment Videos

Last Updated: Jul 2, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.6K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.7K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

838

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Fast-disintegrating electrospun fibers are advanced oral drug delivery systems.
  • These fibers offer high surface area, porosity, and tunable hydrophilicity for rapid drug release.

Purpose of the Study:

  • To review recent advancements in fast-disintegrating electrospun fibers for oral drug delivery.
  • To analyze fiber composition, structural modifications, and drug encapsulation methods.
  • To discuss challenges and future directions in this field.

Main Methods:

  • Systematic literature search conducted in Web of Science, Google Scholar, and Scopus.
  • Keywords used: ('fast-disintegrating' OR 'fast-dissolving') AND ('electrospinning' OR 'electrospun') AND ('delivery' OR 'release').
  • Focus on experimental studies published between 2019 and 2025.

Main Results:

  • Hydrophilic polymers and cyclodextrins accelerate fiber disintegration and improve solubility of hydrophobic drugs.
  • Fiber composition and structural modifications significantly impact drug release profiles.
  • Optimized fibers enhance drug bioavailability for improved therapeutic outcomes.

Conclusions:

  • Fast-disintegrating electrospun fibers show great promise for oral drug delivery.
  • Further research into material selection and structural engineering can optimize drug release and patient compliance.
  • Addressing current challenges will pave the way for clinical translation.