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Advanced electrospun nanofibrous architectures for multidrug delivery systems
1Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Sariyer, 34467, Istanbul, Turkey. topuzf@itu.edu.tr.
Chemical Communications (Cambridge, England)
|July 22, 2026
Summary
Advanced electrospun materials offer precise control for multi-drug combination therapy, improving treatment for complex diseases. Structural design significantly influences drug release kinetics and therapeutic outcomes.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Complex diseases often require multi-drug therapy to overcome resistance and enhance patient outcomes.
- Electrospinning is a versatile technique for creating fibrous materials capable of delivering multiple drugs.
Purpose of the Study:
- To review recent advancements in electrospun structures for multi-drug combination therapy.
- To emphasize the influence of structural design on drug release behavior.
Main Methods:
- Coaxial and multiaxial electrospinning for core-shell structures.
- Bilayer and multilayer electrospinning for programmed release.
- Janus and side-by-side fiber fabrication for spatially distinct delivery.
Main Results:
- Bilayer/multilayer structures facilitate sustained and programmed drug release.
- Core-shell architectures ensure synchronized delivery and minimize burst release.
- Janus/side-by-side fibers enable co-delivery of incompatible agents.
Conclusions:
- Electrospun fiber architecture critically dictates drug release profiles for combination therapy.
- Material selection, drug loading, and release kinetics are key considerations.
- Scalability, safety, and regulatory hurdles must be addressed for clinical translation.
