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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Ferroptosis-associated microRNAs: Systematic review
Maria Del Carmen Candia Plata1, Juan Manuel Martínez Soto2, Jeanette Guadalupe Arredondo Damián3
1Department of Medicine and Health Sciences, University of Sonora, Hermosillo, Sonora, México. carmen.candia@unison.mx.
Abstract:
Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, has emerged as a critical process in various diseases. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, are increasingly recognized as key modulators of ferroptosis pathways. This systematic review aims to provide a comprehensive overview of the current knowledge regarding miRNAs implicated in ferroptosis across a spectrum of diseases. We conducted a systematic search of EMBL-EBI, PubMed, Scopus, and Web of Science databases to identify relevant studies published up to October 31, 2022. Our search strategy identified 127 articles encompassing 107 distinct miRNAs that influence ferroptosis. This review synthesizes the findings of these studies, highlighting the specific miRNAs that act as either inhibitors or inducers of ferroptosis in different disease contexts, including various cancers (e.g., lung, breast, colorectal) and degenerative conditions (e.g., acute renal failure, diabetic retinopathy). We discuss the molecular mechanisms by which these miRNAs regulate ferroptosis, often by targeting key genes involved in iron metabolism, lipid peroxidation, and antioxidant defense. Furthermore, we explore the potential of these miRNAs to serve as diagnostic biomarkers and therapeutic targets in ferroptosis-related disorders, offering insights into novel strategies for disease management.
Insights
MicroRNAs (miRNAs) are key regulators of ferroptosis, an iron-dependent cell death process. This review details how 107 miRNAs influence ferroptosis in diseases like cancer and degenerative conditions, offering potential biomarkers and therapeutic targets.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Ferroptosis is an iron-dependent cell death pathway involving lipid peroxidation.
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in disease pathogenesis.
- Dysregulation of ferroptosis is linked to various diseases, including cancers and degenerative conditions.
Purpose of the Study:
- To systematically review and synthesize current knowledge on miRNAs involved in ferroptosis.
- To identify specific miRNAs that inhibit or induce ferroptosis in different disease contexts.
- To explore the potential of miRNAs as diagnostic biomarkers and therapeutic targets for ferroptosis-related disorders.
Main Methods:
- Systematic literature search of EMBL-EBI, PubMed, Scopus, and Web of Science databases.
- Inclusion of studies published up to October 31, 2022.
- Analysis of 127 articles identifying 107 distinct miRNAs influencing ferroptosis.
Main Results:
- Identified 107 distinct miRNAs that modulate ferroptosis.
- Highlighted miRNAs acting as ferroptosis inhibitors or inducers in cancers (lung, breast, colorectal) and degenerative diseases (acute renal failure, diabetic retinopathy).
- Detailed molecular mechanisms involving miRNA targeting of genes in iron metabolism, lipid peroxidation, and antioxidant defense.
Conclusions:
- miRNAs are crucial regulators of ferroptosis across diverse diseases.
- Specific miRNAs show potential as diagnostic biomarkers for ferroptosis-related conditions.
- miRNAs represent promising therapeutic targets for novel disease management strategies.
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