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Updated: May 10, 2025
11:27
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
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Exploring starch-based excipients in pharmaceutical formulations: Versatile applications and future perspectives.
Devesh U Kapoor1, Anil Pareek2, Mayank Sharma3
1Dr. Dayaram Patel Pharmacy College, Bardoli, Gujarat 394601, India.
Summary
Starch excipients enhance drug formulations through various modifications. These biodegradable and cost-effective materials offer improved stability, drug release, and potential for personalized medicine.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Starch is a natural, biocompatible polysaccharide widely used in pharmaceutical formulations.
- It functions as a key excipient, improving drug stability, efficacy, and manufacturability.
Purpose of the Study:
- To review the properties, modifications, and applications of starch-based excipients in pharmaceuticals.
- To highlight starch's advantages and future potential in drug delivery systems.
Main Methods:
- Literature review of starch properties, modifications, and applications.
- Analysis of starch's role as a binder, disintegrant, and in advanced drug delivery systems.
Main Results:
- Native starches (corn, potato, rice, wheat) are effective disintegrants, binders, and fillers.
- Modifications (physical, chemical, enzymatic) enhance starch functionality for improved stability and targeted delivery.
- Starch offers biodegradability, non-toxicity, and cost-effectiveness compared to other excipients.
Conclusions:
- Starch-based excipients are versatile and advantageous in pharmaceutical formulations.
- Innovations like starch nanocrystals and applications in 3D printing show significant future potential for sustainable drug development.
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