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Updates in the Understanding of Immunoglobulin Replacement Therapy in Primary Immune Deficiency Disorders: Function,
Talal Mousallem1, Geoffrey Hall1, Alice Pan2
1Division of Allergy/Immunology, Department of Pediatrics, Duke University Medical Center, 133 MSRB, Box 2644, Durham, NC 27710, USA.
Abstract:
Clinical indications for immunoglobulin therapy can be broadly classified into replacement therapy for immunodeficiencies, immunomodulatory treatment of inflammatory conditions, and hyperimmune therapy against specific infectious agents. When starting immunoglobulin therapy, there are important considerations for the clinician including indication and function, composition, dosing, route, and safety. Immunoglobulin therapy should be tailored to an individual patient. This review discusses our current understanding and practical considerations for using immunoglobulin therapy for both humoral immune reconstitution and immunomodulation.
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