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Triglyceride-Glucose Index as a predictor of severity in acute pancreatitis: Systematic Review and Meta-Analysis
Gustavo Adolfo Vásquez-Tirado1, Odett Yamile Aguirre-Varas1, Edinson Dante Meregildo-Rodríguez2
1Facultad de Medicina Humana, Universidad Privada Antenor Orrego, Trujillo, Peru.
Objective:
The triglyceride-glucose (TyG) index has been proposed as a novel predictive variable of severe acute pancreatitis (SAP) DESIGN: Systematic review and meta-analysis.
Setting:
A comprehensive search was conducted across five databases of studies published up to March 17, 2024, using the PECO strategy. Seven studies were identified and included in our meta-analysis.
Participants:
The participants of the included primary studies (non-severe acute pancreatitis).
Interventions:
High triglyceride-glucose (TyG) index MAIN VARIABLES OF INTEREST: Severe acute pancreatitis, RESULTS: Our analysis evaluated the risk of progression to severity in patients with elevated TyG index in acute pancreatitis through four non-randomized studies. The TyG index was found to be a predictor of severity in acute pancreatitis, with an overall severity risk (OR: 2.38; 95% CI: 1.50-4.08; I²: 80%). Additionally, the analysis of the standardized mean difference (SMD) across all seven studies between patients with SAP and non-SAP yielded an overall mean (OR: 0.90; 95% CI: 0.70-1.11; I²: 28%).
Conclusion:
In patients with acute pancreatitis, a TyG index is a predictor of severity.
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