NAD augmentation as a disease-modifying strategy for neurodegeneration

Area of Science:

• Neuroscience
• Biochemistry
• Pharmacology

Background:

• Neurodegenerative diseases (NDDs) present a growing global health challenge with no effective disease-modifying therapies.
• NAD augmentation is an emerging strategy targeting critical pathways in NDDs, including mitochondrial dysfunction, energy deficits, proteostasis, and neuroinflammation.

Purpose of the Study:

• To discuss the rationale and evolving therapeutic landscape of NAD augmentation for NDDs.
• To highlight the need for context-specific research to optimize NAD supplementation efficacy.

Main Methods:

• Review of current literature on NAD augmentation in neurodegenerative diseases.
• Analysis of early clinical trial data and ongoing research.

Main Results:

• NAD augmentation targets multiple key disease pathways implicated in NDDs.
• Several clinical trials are underway, indicating significant interest and progress in the field.

Conclusions:

• NAD augmentation holds therapeutic potential for neurodegenerative diseases.
• Identifying specific contexts and addressing knowledge gaps are crucial for realizing the full potential of NAD supplementation.