Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Repeated insertions at positions 261-280 in KPC-2 highlight a ceftazidime-avibactam resistance hotspot.

iScience·2026

Same author

Differential autonomic contributions to persistent hypotension and bradycardia following carotid artery stenting.

Journal of neurointerventional surgery·2026

Same author

Plasmid-borne <i>mcr-4.3</i> in <i>Acinetobacter nosocomialis</i> recovered from imported beef cattle: Genomic characterization and one health implications.

One health (Amsterdam, Netherlands)·2026

Same author

Foundation model for screening severe mitral regurgitation and severe aortic stenosis from coronary angiograms.

Visual computing for industry, biomedicine, and art·2026

Same author

MurineCyto-Det: A High-Resolution Murine BALF Cytology Dataset for Leukocyte Segmentation and Detection.

bioRxiv : the preprint server for biology·2026

Same author

The Vagus Nerve conducts viable translocation of gut flora to the lungs that impacts interstitial lung disease severity in mice.

bioRxiv : the preprint server for biology·2026

Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026

Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026

Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026

Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026

Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026

Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 10, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

MetaHiCNet: a web server for normalizing and visualizing microbial Hi-C interaction networks.

Chentong Sun¹, Zhen Qin¹, Ruishan Liu²

¹Department of Electrical and Computer Engineering, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.

Nucleic Acids Research

|April 27, 2025

Summary

This summary is machine-generated.

MetaHiCNet simplifies microbial genome analysis by offering user-friendly normalization and visualization for metagenomic Hi-C (metaHi-C) data. This platform enhances the study of microbial interactions and community dynamics.

More Related Videos

Capturing Chromosome Conformation Across Length Scales

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

Related Experiment Videos

Last Updated: May 10, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Capturing Chromosome Conformation Across Length Scales

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

Area of Science:

Microbiology
Genomics
Bioinformatics

Background:

Metagenomic Hi-C (metaHi-C) reveals microbial genome organization and interactions.
Raw metaHi-C data contain biases and spurious contacts, hindering analysis.
Existing pipelines lack accessible normalization and visualization tools.

Purpose of the Study:

Introduce MetaHiCNet, a web platform for metaHi-C data analysis.
Provide user-friendly normalization and visualization for microbial interaction networks.
Facilitate deeper insights into microbial community structures and dynamics.

Main Methods:

MetaHiCNet offers customizable normalization methods for bias correction.
The platform implements stepwise workflows for spurious contact removal.
Interactive visualization modes include taxonomic treemaps and cross-taxa networks.

Main Results:

MetaHiCNet enables seamless exploration from community-wide to specific taxon analyses.
The platform supports investigation of host-microbe interactions.
It aids in understanding relationships between mobile genetic elements and hosts.

Conclusions:

MetaHiCNet enhances the analysis of microbial genome organization and interactions.
The platform democratizes metaHi-C data exploration with intuitive tools.
Accessible insights into microbial communities are now more readily available.