Related Experiment Video

Updated: May 13, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.6K

Treatment adherence in patients with multiple sclerosis: risk factors

L A Rodríguez de Antonio1, R Fernández de Córdoba-García2, N Herrero-Muñoz3

  • 1Servicio de Neurología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.

Neurologia
|April 27, 2025
PubMed
Abstract

Insights

Cognitive impairment and alcohol or drug use significantly increase the risk of poor adherence to multiple sclerosis treatments. Oral medications, however, are associated with better adherence in MS patients.

Area of Science:

  • Neurology
  • Pharmacology
  • Public Health

Background:

  • Treatment adherence is crucial for managing multiple sclerosis (MS).
  • Identifying risk factors for non-adherence can improve treatment outcomes.
  • Disease-modifying therapies (DMTs) are central to MS management.

Purpose of the Study:

  • To identify demographic, clinical, and therapeutic risk factors for inadequate adherence to DMTs in patients with MS.
  • To assess the impact of specific patient characteristics and treatment modalities on adherence.
  • To provide evidence for targeted interventions to improve adherence in MS.

Main Methods:

  • Retrospective study analyzing medical records and pharmaceutical dispensing data from 2004-2022.
  • Inclusion of 284 patients with MS and 546 DMT treatments.
  • Multivariate logistic regression to identify factors associated with adherence.

Main Results:

  • Overall adherence rate was 87.5%.
  • Non-adherent patients were more likely to have cognitive impairment, psychiatric conditions, polypharmacy, and alcohol/drug use.
  • Cognitive impairment (OR: 3.82) and alcohol/drug use (OR: 22.83) were significant risk factors for non-adherence.
  • Oral medications were associated with better adherence (OR: 0.29).

Conclusions:

  • Cognitive impairment and alcohol or drug use are major risk factors for low therapeutic adherence in MS.
  • Interventions targeting these factors may improve adherence.
  • Oral DMTs appear to enhance patient adherence in multiple sclerosis management.
Keywords:
AdherenceAdherenciaAlcoholCognitive impairmentDeterioro cognitivoDispensaciónDispensationDrogasDrugsEsclerosis múltipleFarmaciaMultiple sclerosisPharmacyTratamientoTreatment

More Related Videos

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

16.7K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

57.7K

Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
30
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
348
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
33
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
31
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.7K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
96