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Updated: Jun 9, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
[Hypercoagulability and ischemic stroke in young patients]
M Martínez-Martínez1, R Cazorla-García, L A Rodríguez de Antonio
1Servicio de Neurología, Centro de Ictus, Hospital Universitario La Paz, IdiPaz, Renevas, Universidad Autónoma de Madrid, Madrid, España.
Neurologia (Barcelona, Spain)
|August 27, 2010
Summary
Hypercoagulable states are common in young adults experiencing ischemic stroke, affecting nearly half of patients. These prothrombotic abnormalities, including hyperhomocysteinemia and factor V Leiden, are frequent in this demographic.
Area of Science:
- Neurology
- Hematology
- Genetics
Context:
- Cerebral venous thrombosis is linked to hypercoagulable states.
- Arterial ischemic stroke in young patients may also be influenced by these conditions.
- Understanding these risk factors is crucial for effective management and prevention strategies.
Purpose:
- To investigate the prevalence of prothrombotic abnormalities in young patients with ischemic stroke.
- To identify specific hypercoagulable states common in this patient group.
- To explore potential associations between these states and stroke characteristics or outcomes.
Summary:
- A study of 100 patients under 55 with ischemic stroke found that 46% had a hypercoagulable state.
- Acquired hyperhomocysteinemia (18%) was the most frequent abnormality, followed by protein C or S deficiency (8%) and factor V Leiden mutation (5%).
- No significant association was found with stroke severity or outcomes, but a trend emerged for atherothrombotic stroke.
Impact:
- Highlights the high frequency of hypercoagulable states in young ischemic stroke patients.
- Suggests that screening for prothrombotic abnormalities may be warranted in this population.
- Informs therapeutic management and secondary prevention approaches for young stroke survivors.
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