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Evidence and Consensus-Based Imaging Guidelines in Multifocal Choroiditis With Panuveitis and Punctate Inner
Sapna Gangaputra1, Aniruddha Agarwal2, Jeannette Ossewaarde-van Norel3
1Vanderbilt Eye Institute (S.G.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
American Journal of Ophthalmology
|April 27, 2025
Summary
Multimodal imaging guidelines for noninfectious multifocal choroiditis and panuveitis (MFCPU) and punctate inner choroiditis (PIC) were developed. Optical coherence tomography (OCT) is key for detecting active lesions and monitoring recurrence.
Area of Science:
- Ophthalmology
- Medical Imaging
- Inflammatory Eye Diseases
Background:
- Noninfectious multifocal choroiditis and panuveitis (MFCPU) and punctate inner choroiditis (PIC) are inflammatory eye conditions.
- Accurate diagnosis and monitoring are crucial for effective management.
Purpose of the Study:
- To establish consensus-based guidelines for using multimodal imaging in MFCPU and PIC.
- To define imaging characteristics, activity biomarkers, and complications for these conditions.
Main Methods:
- Expert committee review of literature and case studies.
- Nominal group technique (NGT) for consensus on imaging modalities (CFP, OCT, FFA, OCTA, ICGA, FAF).
- Voting by task force on recommendations for MFCPU and PIC.
Main Results:
- Color fundus photography (CFP) characterizes lesions; OCT is preferred for active lesions.
- FAF and OCT effectively monitor disease recurrence.
- Late-phase ICGA is valuable for recurrent disease; OCTA/ICGA identify lesions but not activity status.
Conclusions:
- Integrating imaging, especially OCT, improves MFCPU/PIC assessment within SUN criteria.
- Guidelines aid in selecting optimal imaging for diagnosis, monitoring, and complication identification.
