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Updated: May 1, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Bioengineered nanomaterials for dynamic diagnostics in vivo.

Jizhong Wu¹, Xinyu Zhou², Chung Yin Tsang¹

¹Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore.

Chemical Society Reviews

|April 28, 2025

Summary

This summary is machine-generated.

Bioengineered nanomaterials enable advanced in vivo dynamic diagnostics for real-time disease monitoring. These materials overcome challenges in deep tissue imaging, paving the way for improved clinical applications.

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Area of Science:

Biomedical Engineering
Nanotechnology
Medical Diagnostics

Background:

In vivo diagnostics offer superior accuracy over ex vivo methods by acquiring real-time physiological data.
In vivo dynamic diagnostics provide continuous monitoring for deeper insights into disease pathogenesis and progression.
Current in situ dynamic diagnostics in deep tissues face limitations in energy/signal penetration and continuous monitoring.

Purpose of the Study:

To review fundamental components for in vivo dynamic diagnostics using bioengineered nanomaterials.
To summarize recent advancements (last five years) in the field.
To discuss challenges and solutions for clinical translation of these technologies.

Main Methods:

Review of studies focusing on bioengineered nanomaterials for in vivo dynamic diagnostics.
Analysis of essential components: energy sources, responsive nanomaterials, nanoprobe design, and signal analysis.
Discussion of energy sources like near-infrared (NIR) light, X-rays, magnetic fields, and ultrasound.
Exploration of signal detection methods including optical, radiation, magnetic, and ultrasound signals.

Main Results:

Bioengineered nanomaterials are ideal platforms for in vivo dynamic diagnostics due to energy conversion and biofunctionalization.
Key components include high-penetration energy sources, responsive nanomaterials, specifically designed nanoprobes, and advanced signal analysis techniques.
Nanoprobes can be engineered for spatial, temporal, or spatiotemporal signal changes.

Conclusions:

Bioengineered nanomaterials offer a promising approach to overcome current limitations in deep-tissue in vivo dynamic diagnostics.
Further research and development are crucial for addressing obstacles to clinical translation.
These advancements hold potential for revolutionizing disease diagnosis and monitoring.