Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary concentrations of temocillin.

F Spelsberg, A Bauernfeind, W Wiest

    Drugs
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Survival after neoadjuvant chemotherapy with or without bevacizumab or everolimus for HER2-negative primary breast cancer (GBG 44-GeparQuinto)†.

    Annals of oncology : official journal of the European Society for Medical Oncology·2014
    Same author

    Resection of pulmonary metastases from colon and rectal cancer: factors to predict survival differ regarding to the origin of the primary tumor.

    Annals of surgical oncology·2014
    Same author

    [Non-curable tumours of the female genital tract: therapeutic options in bowel stenosis and bleeding].

    Zentralblatt fur Chirurgie·2011
    Same author

    Treatment of a completely obstructed colonic anastomotic stricture using a CT-guided endoscopic rendezvous technique.

    Endoscopy·2011
    Same author

    First-line therapy with moderate dose capecitabine in metastatic breast cancer is safe and active: results of the MONICA trial.

    European journal of cancer (Oxford, England : 1990)·2010
    Same author

    An evaluation of the activity of cephalosporins against Pseudomonas aeruginosa.

    The Journal of antimicrobial chemotherapy·2009
    Same journal

    Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

    Drugs·2026
    Same journal

    Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

    Drugs·2026
    Same journal

    Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

    Drugs·2026
    Same journal

    Relacorilant: First Approval.

    Drugs·2026
    Same journal

    Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

    Drugs·2026
    Same journal

    Linerixibat: First Approval.

    Drugs·2026
    See all related articles

    Temocillin achieved high concentrations in bile for patients with biliary tract infections, exceeding minimum inhibitory levels. This antibiotic demonstrated excellent efficacy and safety, leading to successful treatment outcomes.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Biliary tract infections are challenging to treat due to variable drug penetration.
    • Temocillin is a penicillin antibiotic with potential activity against biliary pathogens.

    Purpose of the Study:

    • To evaluate serum and bile concentrations of temocillin.
    • To assess the clinical efficacy and safety of temocillin in patients with biliary tract infections.

    Main Methods:

    • Intravenous administration of 1g temocillin twice daily to 16 patients.
    • Measurement of serum and bile temocillin concentrations.
    • Monitoring of clinical outcomes, side effects, and laboratory data.

    Main Results:

    Related Experiment Videos

  • High inter-individual variations in bile temocillin concentrations were observed.
  • Achieved concentrations in bile were significantly higher than minimum inhibitory concentrations (MICs) for identified pathogens.
  • All patients experienced successful treatment with temocillin.

    • Conclusions:

    • Temocillin effectively penetrates the biliary tract.
    • The drug demonstrates excellent clinical efficacy and a very good safety profile for treating biliary tract infections.