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Updated: May 8, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

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Aging and Lifestyle Modifications for Preventing Aging-Related Diseases

Qiao Li1,2, Heng Zhang1,2, Nanyin Xiao1,2

  • 1Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 28, 2025
PubMed

Insights

Aging accelerates chronic diseases like cardiovascular and neurodegenerative conditions. This review explores molecular anti-aging strategies, including lifestyle changes, to combat age-related health decline.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Chronic Disease Pathogenesis

Background:

  • Aging is linked to chronic diseases affecting cardiovascular, nervous, and musculoskeletal systems.
  • Cellular senescence, driven by impaired autophagy, metabolic imbalance, oxidative stress, and inflammation, underlies organ aging.
  • Societal aging necessitates effective strategies to mitigate age-related health issues.

Purpose of the Study:

  • To review molecular mechanisms of aging.
  • To elucidate the significance of anti-aging interventions.
  • To provide a reference for preventing and treating age-related diseases.

Main Methods:

  • Literature review of research on aging mechanisms.
  • Analysis of molecular pathways involved in cellular senescence.
  • Evaluation of lifestyle modifications and their anti-aging effects.

Main Results:

  • Aging impacts multiple organ systems, leading to diseases like atherosclerosis and Alzheimer's.
  • Cellular senescence involves complex molecular processes.
  • Lifestyle interventions like exercise and calorie restriction show anti-aging potential.

Conclusions:

  • Understanding molecular aging mechanisms is crucial for developing interventions.
  • Lifestyle modifications offer promising strategies for healthy aging.
  • This review serves as a resource for managing age-related diseases in an aging population.

Keywords:
agingaging‐related diseasescellular senescencelifestyle modifications

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