Activatable Chemodynamic Theranostics through Molecular Imaging-Energized Companion Diagnostics
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Updated: Jun 12, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Meng Li1,2, Yafei Zhang1, Yumeng Wu1
1Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518055, China.
Abstract:
Chemodynamic therapy (CDT) is a promising tumor treatment strategy, yet real-time in vivo monitoring remains challenging. Here, we report an activatable molecular imaging-energized companion diagnostics sensor (CFG) for real-time monitoring of CDT. CFG leverages glucose oxidase (GOx) to generate hydrogen peroxide to prime the Fenton reaction, while simultaneously producing H+ to activate the fluorescence (FL) and photoacoustic (PA) signals. A positive correlation between the FL/PA intensities and the Fenton reaction efficiency is found (Pearson's r = 0.98 for ·OH-FL, 0.90 for ·OH-PA), enabling dynamic visualization of the GOx catalysis-primed CDT. Also, H+-activated photothermal effect of CFG enables FL/PA imaging to pinpoint the optimal irradiation time for maximizing mild hyperthermia-enhanced CDT. Therefore, by tracing the H+ dynamics, tailored feedback is collected for therapeutic response monitoring and treatment guidance, and the cascade effect between enzyme catalysis, mild hyperthermia, and CDT is revealed.
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