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Activatable Chemodynamic Theranostics through Molecular Imaging-Energized Companion Diagnostics
Meng Li1,2, Yafei Zhang1, Yumeng Wu1
1Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518055, China.
This study introduces a novel sensor for real-time monitoring of chemodynamic therapy (CDT) in vivo. The sensor uses glucose oxidase (GOx) to activate imaging signals and guide treatment, improving tumor therapy effectiveness.
Area of Science:
- Biomedical Engineering
- Molecular Imaging
- Cancer Therapy
Background:
- Chemodynamic therapy (CDT) shows promise for cancer treatment.
- Real-time in vivo monitoring of CDT remains a significant challenge.
- Developing companion diagnostics for CDT is crucial for effective treatment.
Purpose of the Study:
- To develop an activatable molecular imaging-energized companion diagnostics sensor (CFG) for real-time monitoring of CDT.
- To enable dynamic visualization of CDT processes.
- To guide and optimize hyperthermia-enhanced CDT.
Main Methods:
- Utilized glucose oxidase (GOx) to generate hydrogen peroxide for Fenton reaction priming.
- Engineered CFG to produce H+ for activating fluorescence (FL) and photoacoustic (PA) signals.
- Correlated FL/PA intensities with Fenton reaction efficiency and monitored H+ dynamics.
Main Results:
- Demonstrated a positive correlation between FL/PA intensities and Fenton reaction efficiency (Pearson's r = 0.98 for ·OH-FL, 0.90 for ·OH-PA).
- Achieved dynamic visualization of GOx catalysis-primed CDT.
- Showcased H+-activated photothermal effect for optimizing mild hyperthermia-enhanced CDT.
Conclusions:
- CFG enables real-time monitoring and feedback for CDT.
- Tracing H+ dynamics provides tailored guidance for therapeutic response.
- Revealed the cascade effect between enzyme catalysis, mild hyperthermia, and CDT for enhanced treatment outcomes.
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