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Updated: May 9, 2025

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
Putting AML Differentiation States on the BoneMarrowMap
Jonas Berger1, Livius Penter1,2,3
1Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow Klinikum, Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Abstract:
This article presents a novel computational tool, "BoneMarrowMap," that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By utilizing BoneMarrowMap for a large-scale single-cell RNA sequencing reanalysis, the authors discover 12 recurrent acute myeloid leukemia differentiation patterns linked to prognosis and treatment and dissect leukemic clonal architectures within individual patients. See related article by Zeng and colleagues, p. 307.
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