Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

2.9K
Commitment is the  process whereby stem cells:
2.9K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

260
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
260
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.6K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.6K
Hematopoiesis01:21

Hematopoiesis

4.9K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
4.9K
Production of Formed Elements01:34

Production of Formed Elements

1.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Not all Tregs in MDS are created equal.

British journal of haematology·2026
Same author

Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.

Genome biology·2026
Same author

Clonal hematopoiesis and lymphoma-associated mutations in hematopoietic progenitors in B-cell non-Hodgkin lymphoma.

Blood·2026
Same author

Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.

Nature·2025
Same author

Mechanisms of immune escape and extramedullary tropism in leukemia cutis.

Blood·2025
Same author

A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence.

Nature communications·2025

Related Experiment Video

Updated: May 9, 2025

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

11.5K

Putting AML Differentiation States on the BoneMarrowMap.

Jonas Berger1, Livius Penter1,2,3

  • 1Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow Klinikum, Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Blood Cancer Discovery
|April 28, 2025
PubMed
Summary

A new tool, BoneMarrowMap, maps leukemia cell data to blood cell development. This reveals 12 acute myeloid leukemia patterns affecting prognosis and treatment, aiding in understanding disease complexity.

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.1K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

2.9K

Related Experiment Videos

Last Updated: May 9, 2025

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

11.5K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.1K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

2.9K

Area of Science:

  • Hematology
  • Computational Biology
  • Oncology

Background:

  • Acute myeloid leukemia (AML) is a complex blood cancer.
  • Understanding leukemic cell differentiation is crucial for prognosis and treatment.
  • Single-cell RNA sequencing (scRNA-seq) offers high-resolution insights into cellular heterogeneity.

Purpose of the Study:

  • To introduce BoneMarrowMap, a novel computational tool for analyzing scRNA-seq data in leukemia.
  • To map leukemic cells to normal hematopoietic differentiation trajectories.
  • To identify AML-specific differentiation patterns and their clinical relevance.

Main Methods:

  • Development of the BoneMarrowMap computational tool.
  • Application of BoneMarrowMap to large-scale scRNA-seq datasets of AML.
  • Reanalysis of AML scRNA-seq data to identify differentiation patterns.
  • Correlation of identified patterns with patient prognosis and treatment outcomes.

Main Results:

  • BoneMarrowMap successfully maps leukemic cells to hematopoietic differentiation states.
  • Identification of 12 recurrent AML differentiation patterns.
  • These patterns are significantly associated with patient prognosis and treatment response.
  • Dissection of leukemic clonal architectures within individual AML patients.

Conclusions:

  • BoneMarrowMap is a valuable tool for dissecting AML heterogeneity using scRNA-seq data.
  • The discovered AML differentiation patterns offer new insights into disease biology.
  • These findings have implications for improving AML prognosis and treatment strategies.