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Iron-Catalyzed Regioselective C═C Bond Migration and Reductive Deuteration
Qiuting Zhao1, Congrong Li1, Hongjie Gao1
1College of Chemistry, Beijing Normal University, Beijing 100875, China.
Abstract:
We report a well-defined multifunctional iron catalyst, Cp*Fe(Ph2PN = C5H4N), that promotes the rearrangement of β,γ-unsaturated ketones, esters, and amides to their α,β-isomers, enabling regioselective C═C reductive deuteration. This iron-catalyzed protocol showcases the synthesis of a diverse range of α,β-dideuterated organic compounds, demonstrating broad substrate compatibility under mild conditions. Mechanism studies provide insights into the C═C bond relocation and cooperative D2 activation.
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