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Published on: January 9, 2018
Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation
Julia R Port1, Claude Kwe Yinda2, Claire Ruckel2
1Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. julia.port@nih.gov.
Abstract:
The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.
