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Published on: March 1, 2019
Quasispecies theory and emerging viruses: challenges and applications
Josep Sardanyés1,2, Celia Perales3,4, Esteban Domingo5
1Centre de Recerca Matemàtica (CRM), Edifici C, Campus de Bellaterra, Cerdanyola del Vallès, Barcelona, Spain. jsardanyes@crm.cat.
Abstract:
Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory's role in virus-host interactions, including immune evasion, drug resistance, and viral emergence. We review the original model, recent advances, and key virus dynamics needing incorporation into quasispecies theory. We introduce the ultracube concept as a more realistic multidimensional sequence space to investigate virus evolutionary dynamics.
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