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The human microbiome: redefining cancer pathogenesis and therapy.
Yogita K Adlakha1, Ravindresh Chhabra2
1Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Sector-125, Noida, Uttar Pradesh, 201303, India. yadlakha@amity.edu.
Cancer Cell International
|April 28, 2025
Summary
The human microbiome influences cancer development and treatment. Modifying gut microbes may improve cancer therapy effectiveness and patient outcomes, offering new diagnostic and therapeutic strategies.
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- The human microbiome plays a crucial role in maintaining health.
- Emerging evidence links the microbiome to cancer initiation, progression, and treatment response.
Purpose of the Study:
- To review the scientific evidence connecting the human microbiome to cancer.
- To explore the mechanisms by which microbiota influence cancer.
- To evaluate the potential of microbiome-based cancer therapies.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of the microbe-cancer axis.
- Evaluation of therapeutic strategies targeting the microbiome.
Main Results:
- Altered microbiome composition can promote cancer progression and affect chemoresistance.
- Microbiome modulation can enhance sensitivity to cancer drugs.
- Microbial biomarkers show potential for cancer diagnostics.
Conclusions:
- The human microbiome is significantly involved in cancer development and progression.
- Targeting the microbiome offers novel therapeutic strategies for cancer treatment.
- Further research into the microbe-cancer axis can lead to improved patient outcomes.
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