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A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
Published on: October 25, 2024
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Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis
Di Xue1, Xiaolei Chen2, Lufei Shao3
1Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China.
Journal of Orthopaedic Surgery and Research
|April 28, 2025
Summary
The Nutritional Risk Screening 2002 (NRS-2002) score, recurrent pulmonary tuberculosis (PTB), and poverty are key predictors for progression to spinal tuberculosis (STB). Early identification and intervention for these factors can significantly reduce STB risk.
Area of Science:
- Infectious Diseases
- Public Health
- Clinical Medicine
Background:
- Pulmonary tuberculosis (PTB) can progress to extrapulmonary forms, including spinal tuberculosis (STB).
- Identifying risk factors for PTB to STB progression is crucial for timely intervention and improved patient outcomes.
- Understanding these risk factors aids in optimizing treatment strategies and enhancing patient prognosis.
Purpose of the Study:
- To identify significant risk factors associated with the progression from pulmonary tuberculosis (PTB) to spinal tuberculosis (STB).
- To evaluate the predictive value of the Nutritional Risk Screening 2002 (NRS-2002) score in STB progression.
- To inform early disease intervention and public health strategies for STB prevention.
Main Methods:
- Retrospective analysis of 326 patients diagnosed with PTB.
- Collection of demographic, clinical, and socioeconomic data, including NRS-2002 scores and history of recurrent PTB.
- Application of univariate and multivariate logistic regression, interaction effect analysis, and risk stratification based on NRS-2002 scores.
Main Results:
- The NRS-2002 score, recurrent PTB, and living in relative poverty were identified as significant risk factors in univariate analysis.
- Multivariate analysis confirmed NRS-2002 score (OR=11.22), recurrent PTB (OR=5.08), and poverty (OR=2.58) as independent predictors of STB progression.
- A strong dose-response relationship was observed between NRS-2002 scores and STB progression risk, with scores ≥6 showing the highest odds (OR=91.59).
Conclusions:
- The NRS-2002 score, recurrent PTB, and socioeconomic status (poverty) are critical risk factors for PTB to STB progression.
- The NRS-2002 score is a highly significant predictor, demonstrating a clear dose-response relationship.
- Early identification of high-risk patients (elevated NRS-2002 scores), nutritional support, and poverty alleviation are vital for preventing STB development.
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