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HuangE Capsules Improve Bladder Function in BOO-induced Overactive Bladder Rats: Network Pharmacology and
Peizhe Li1, Yuewen Pang1, Shiyu Zhao1
1Department of Urology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Combinatorial Chemistry & High Throughput Screening
|April 29, 2025
Summary
HuangE capsules (HEC) effectively treat overactive bladder (OAB) in rats by improving bladder function and morphology. HEC reduces key inflammatory and oxidative stress markers, offering a potential therapeutic for OAB.
Area of Science:
- Pharmacology
- Urology
- Integrative Medicine
Background:
- Overactive bladder (OAB) significantly impacts quality of life due to urinary urgency and frequency.
- HuangE capsules (HEC) show potential in treating OAB, but mechanisms require elucidation.
Purpose of the Study:
- To evaluate the therapeutic effects of HEC on OAB in a rat model.
- To investigate the underlying mechanisms of HEC action on OAB.
Main Methods:
- Established bladder outlet obstruction (BOO) rat models for OAB.
- Administered HEC and assessed urination frequency, urodynamics, and bladder tissue morphology (Masson staining).
- Analyzed Rho/Rho-kinase pathway, oxidative stress (SOD, MDA), and inflammation (TNF-α, IL-6) markers via Western blotting and ELISA.
Main Results:
- HEC treatment significantly reduced urination frequency and improved urodynamic parameters in OAB rats.
- Histological analysis showed improved bladder morphology and reduced collagen deposition with HEC.
- HEC downregulated RhoA/ROCK pathway proteins and decreased oxidative stress and inflammatory markers.
Conclusions:
- HEC demonstrates therapeutic potential for OAB by enhancing bladder function and morphology.
- The mechanism involves inhibiting the RhoA/ROCK pathway and mitigating oxidative stress and inflammation.
