Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metal-Ligand Bonds

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

Complexation Equilibria: The Chelate Effect

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...

Complexation Equilibria: Factors Influencing Stability of Complexes

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...

Complexometric Titration: Ligands

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Test-retest reliability and validity of movement-evoked pain in patients with knee osteoarthritis: a methodological study protocol.

BMJ open·2026

Same author

Phage and endolysin-based inhibition of <i>Klebsiella pneumoniae</i>: from mechanisms to combination therapies.

Frontiers in cellular and infection microbiology·2026

Same author

The role of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II in oxaliplatin resistance of colorectal cancer: In vitro and in vivo studies.

Gene·2026

Same author

Temozolomide-based therapy may remodel the tumor microenvironment and enhance immunotherapy sensitivity in advanced leiomyosarcoma.

Anti-cancer drugs·2026

Same author

Camrelizumab Plus Apatinib in Advanced Unresectable Alveolar Soft Part Sarcoma and Undifferentiated Pleomorphic Sarcoma Patients: A Single-Center, Exploratory Case Series.

Therapeutics and clinical risk management·2026

Same author

Effects of nocturnal melatonin-based tissue-bone homeostasis manipulation at varying time points on pain and central mechanisms in individuals with knee osteoarthritis: a randomized controlled trial.

Frontiers in bioengineering and biotechnology·2026

Search research articles

Related Experiment Video

Updated: May 9, 2025

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

Enhanced functionalities of biomaterials through metal ion surface modification.

Yujie Tao¹, Wayne Nishio Ayre², Liming Jiang¹

¹School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.

Frontiers in Bioengineering and Biotechnology

|April 29, 2025

Summary

Metal ions like zinc and copper enhance artificial biomaterials for bone repair by promoting bone growth and fighting infection. These materials offer promising clinical applications for bone defect regeneration.

Keywords:

antibacterial activity biomaterials bone defect repair metal ions osteogenesis

More Related Videos

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Related Experiment Videos

Last Updated: May 9, 2025

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Area of Science:

Biomaterials Science
Orthopedic Research
Nanotechnology

Background:

Bone defect repair is a significant clinical challenge.
Metal ions (Zn, Cu, Mg, Ca, Sr, Ag, Ce) are crucial for bone regeneration.
These ions promote osteogenesis, angiogenesis, and possess antibacterial properties.

Purpose of the Study:

To review the mechanisms of metal ion-mediated bone tissue regeneration.
To summarize methods for incorporating metal ions into biomaterials.
To highlight clinical applications of metal ion-functionalized biomaterials.

Main Methods:

Literature review of studies on metal ions in bone regeneration.
Analysis of biochemical functions and effects of specific metal ions.
Summary of metal ion loading techniques onto biomaterial surfaces.

Main Results:

Metal ions promote osteogenesis and angiogenesis at appropriate concentrations.
Zn, Sr, and Ce inhibit osteoclast activity, aiding osteogenesis.
Cu, Mg, and Sr enhance angiogenesis; Zn, Cu, Ag, and Ce provide antibacterial effects.

Conclusions:

Metal ion incorporation enhances biomaterial osteogenic and antibacterial properties.
Functionalized biomaterials show potential for improved bone defect repair.
Further clinical applications are anticipated for these advanced materials.