Related Experiment Video
Updated: May 5, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
Published on: October 22, 2009
Primordial germ cells as a potential model for understanding (Nutri) epigenetic - metabolic interactions: a mini
Mariam Ibrahim1,2, Ewa Grochowska1, Katarzyna Stadnicka1
1Health Sciences Faculty, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
Abstract:
Primordial germ cells (PGCs) are the progenitors of gametes (sperm and eggs), making them crucial for understanding germline transmission and epigenetic modifications, which are critical for studying transgenerational effects of nutrition and metabolic diseases. This is particularly relevant given the growing evidence that environmental factors, such as diet, can influence metabolic disease risk across generations through modulating epigenetic mechanisms, as seen in both human and animal studies. The unique biological and experimental attributes make PGCs in the chicken embryo a potential model for exploring the complex interactions between nutrition, epigenetic inheritance, and metabolic diseases, providing insights that are translatable to metabolic health and disease prevention tactics. This brief review emphasizes the potential of chicken PGCs as a model system to investigate the mechanisms underlying transgenerational metabolic programming.
More Related Videos
13:03Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
Published on: June 3, 2016
12:06Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
Published on: January 11, 2019
Related Concept Videos
Epigenetic Regulation
Meiosis I
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Epigenetic Regulation
X-chromosome...
Somatic to iPS Cell Reprogramming
Methods of Nuclear Reprogramming