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Photo-Thiocyanoamination of π- and σ-Bonds: Reagent Development and Synthetic Applications
Arunima Mukherjee1, Apurba Samanta1, Soumitra Maity1
1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad,Dhanbad, Jharkhand 826004, India.
Abstract:
1,2-Thiocyanoamines make up a class of important structural motifs that are found in a number of bioactive molecules and precursors to many more. Despite their synthetic significance, expedient access to this difunctionalization is rare. Herein, the development of a thiocyanoimination reagent is disclosed, taking advantage of photomediated energy transfer phenomena for the facile thiocyanoimination of alkenes. The strategy was found to be viable for σ-bonds as well, providing a generalized strategy for accessing small molecules infused with amine and -SCN.
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