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Updated: Jan 7, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Unified Photoredox Strategy for Selective Access to Hydroisoquinoline and Benzosultam via Tether Modulation of
Avik Kr Das1, Rabindranath Lo2, Soumitra Maity1
1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM), Dhanbad, Jharkhand 826004, India.
Abstract:
Hydroisoquinoline and benzosultam motifs represent privileged heterocyclic frameworks with broad pharmacological relevance. We report a divergent photoredox strategy that enables selective access to both scaffolds from a simple precursor. The transformation proceeds via radical addition to an unactivated olefin followed by a domino cyclization. While conventional reactivity strongly favors hydroisoquinoline formation, we discovered that chain-length modulation imposes ring strain on the arene pathway, thereby suppressing the competing cyclization and promoting the challenging sulfonyl-arene closure. This strain-guided approach offers a unified entry to hydroisoquinolines and benzosultams under mild conditions, expanding the toolkit for heterocycle synthesis.
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