Primary Submandibular Gland Squamous Cell Carcinoma

Area of Science:

• Oncology
• Head and Neck Surgery
• Pathology

Background:

• Primary submandibular gland squamous cell carcinoma (SCC) is an exceptionally rare malignancy.
• Diagnosis is often challenging, requiring exclusion of other potential primary sites.
• This condition presents unique management difficulties due to its rarity.

Purpose of the Study:

• To report a case of primary submandibular gland SCC.
• To review existing literature on the diagnosis and treatment of this rare cancer.
• To provide insights into optimal management strategies.

Main Methods:

• A case report from the authors' institution was documented.
• A systematic literature search was conducted using PubMed, ScienceDirect, and WileyOnline Library.
• Data extracted included demographics, clinical presentation, histopathology, treatment, and outcomes from 13 previously reported cases.

Main Results:

• Thirteen relevant case reports were identified spanning from 1992 to 2024.
• Key data points such as patient demographics, clinical findings, and treatment modalities were compiled.
• The review highlighted the aggressive nature and diagnostic challenges associated with this malignancy.

Conclusions:

• Primary submandibular gland SCC is a rare, aggressive cancer requiring a diagnosis of exclusion.
• Multidisciplinary team management is crucial for effective treatment.
• Surgery combined with radiotherapy represents the likely optimal treatment approach.