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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Salivary Glands and Saliva01:23

Salivary Glands and Saliva

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The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
295

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Related Experiment Video

Updated: May 9, 2025

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
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Primary Submandibular Gland Squamous Cell Carcinoma.

Jed Speers1, Hannah Walker2, Sameep P Kadakia3

  • 1Boonshoft School of Medicine, Wright State University.

The Journal of Craniofacial Surgery
|April 29, 2025
PubMed
Summary

This case report details primary submandibular gland squamous cell carcinoma (SCC), a rare and aggressive malignancy. Optimal treatment involves a multidisciplinary team, surgery, and radiotherapy for best patient outcomes.

Keywords:
Primary submandibular gland squamous cell carcinomareview of literaturesalivary gland malignancy

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Pathology

Background:

  • Primary submandibular gland squamous cell carcinoma (SCC) is an exceptionally rare malignancy.
  • Diagnosis is often challenging, requiring exclusion of other potential primary sites.
  • This condition presents unique management difficulties due to its rarity.

Purpose of the Study:

  • To report a case of primary submandibular gland SCC.
  • To review existing literature on the diagnosis and treatment of this rare cancer.
  • To provide insights into optimal management strategies.

Main Methods:

  • A case report from the authors' institution was documented.
  • A systematic literature search was conducted using PubMed, ScienceDirect, and WileyOnline Library.
  • Data extracted included demographics, clinical presentation, histopathology, treatment, and outcomes from 13 previously reported cases.

Main Results:

  • Thirteen relevant case reports were identified spanning from 1992 to 2024.
  • Key data points such as patient demographics, clinical findings, and treatment modalities were compiled.
  • The review highlighted the aggressive nature and diagnostic challenges associated with this malignancy.

Conclusions:

  • Primary submandibular gland SCC is a rare, aggressive cancer requiring a diagnosis of exclusion.
  • Multidisciplinary team management is crucial for effective treatment.
  • Surgery combined with radiotherapy represents the likely optimal treatment approach.