Primary Submandibular Gland Squamous Cell Carcinoma

This case report and review examines the rare diagnosis and treatment of primary submandibular gland squamous cell carcinoma (SCC). In this paper, the authors report a case of primary submandibular gland squamous cell carcinoma from their institution. The authors then searched PubMed, ScienceDirect, and WileyOnline Library databases for previous case reports of this disease. The authors collected and reported the following: patient demographics, presentation, physical examination, lymph node involvement, histopathology, treatments, and patient outcomes. Thirteen case reports were found from 1992 to 2024. Primary submandibular gland squamous cell carcinoma, characterized by a diagnosis of exclusion, is a rare and aggressive malignancy best treated by a multidisciplinary team and likely treated with surgery and radiotherapy. Because it is a rare occurrence, it is essential to understand what primary submandibular gland squamous cell carcinoma is and how to best manage patients with this condition.