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The Alzheimer's Disease Continuum - A New Diagnostic Approach
Jonathan Drake1, Scott Warren1, Chuang-Kuo Wu1
1Department of Neurology, Warren Alpert Medical School of Brown University; Rhode Island Hospital Alzheimer's Disease and Memory Disorders Center, Providence, RI.
Rhode Island Medical Journal (2013)
|April 29, 2025
Summary
New Alzheimer
Area of Science:
- Neurology
- Biomarkers
- Disease Management
Background:
- Alzheimer's disease (AD) management is evolving with scientific advancements.
- New therapies increase access to diagnostic tools like amyloid PET imaging.
- Blood-based biomarkers for AD are becoming commercially available.
Purpose of the Study:
- To guide community practitioners in making informed AD diagnostic decisions.
- To highlight emerging challenges in AD diagnosis due to advanced biomarker availability.
- To provide fundamental principles for navigating new AD diagnostic technologies.
Main Methods:
- Review of current scientific progress in Alzheimer's disease.
- Analysis of the impact of new FDA-approved therapies on diagnostics.
- Examination of the role of emerging fluid and imaging biomarkers.
Main Results:
- Community practitioners face increasing responsibility for advanced AD biomarker interpretation.
- Readily available advanced diagnostics present new decision-making challenges.
- Fundamental principles are needed for informed AD diagnostic choices.
Conclusions:
- The landscape of Alzheimer's disease diagnosis is rapidly changing.
- Practitioners require updated knowledge to manage evolving diagnostic options.
- Proactive orientation to new biomarker technologies is crucial for effective AD care.
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