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Behavioral Variant in Alzheimer's Disease.

Chuang-Kuo Wu¹, Jennifer M Dailey², John E Donahue²

¹Department of Neurology, Alzheimer's Disease and Memory Disorders Center, Providence, Rhode Island, USA.

Acta Neurologica Taiwanica

|January 29, 2026

Summary

This review details atypical Alzheimer's disease (AD) variants, focusing on the behavioral variant. It covers new diagnostic criteria and management strategies for improved clinical practice in neurology.

Keywords:

Alzheimer amyloid tracer brain positron emission tomography behavioral dysexecutive syndrome frontal frontotemporal dementia

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Area of Science:

Neurology
Neuroscience
Geriatrics

Background:

Alzheimer's disease (AD) typically presents with memory loss, but atypical variants exist.
The behavioral variant of AD (bvAD) is characterized by prominent changes in personality and behavior.
Understanding these variants is crucial for accurate diagnosis and effective management.

Purpose of the Study:

To review the development and discovery of atypical variants in Alzheimer's disease.
To provide a detailed comparison of the behavioral variant of AD with other AD presentations.
To explain and apply newly developed diagnostic criteria and approaches for clinical neurology practice.

Main Methods:

Literature review focusing on atypical Alzheimer's disease variants.
Detailed description and comparison of the behavioral variant of AD.
Explanation and application of novel diagnostic criteria and approaches.
Case study analysis to illustrate pathophysiological variations.

Main Results:

Atypical variants, particularly the behavioral variant of AD, are increasingly recognized.
New diagnostic criteria and approaches enhance the identification of bvAD.
Management and treatment principles for bvAD are outlined.
Case reports highlight diverse pathophysiological pathways in bvAD.

Conclusions:

Atypical variants of Alzheimer's disease, especially bvAD, require specific diagnostic and management strategies.
The reviewed diagnostic criteria offer a framework for clinical application in neurology.
Further research into the pathophysiology of bvAD is warranted.