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Published on: July 1, 2013
Inflammatory and Antioxidant Status in Peri-Implant Health and Diseases: A Biochemical Analysis
Poulami Chakraborty1, Arvina Rajasekar2
1Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Background:
Peri-implant disease pathogenesis results in production of pro-inflammatory mediators. These mediators alter the redox balance leading to decrease in antioxidants. The aim of the study was to compare the levels of interleukin-6 (IL-6) and superoxide dismutase (SOD) in peri-implant health and diseases.
Materials And Methods:
The present observational study was carried out from March 2023 to September 2023 in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 60 patients with peri-implant health (n = 20), peri-implant mucositis (n = 20) and peri-implantitis (n = 20) were enrolled. Unstimulated salivary samples were collected and subjected to ELISA for IL-6 and SOD analysis. IL-6 and SOD levels were then compared between the groups using ANOVA.
Results:
There was a statistically significant difference in IL-6 and SOD levels between the three groups with p value of 0.003 and 0.000 respectively.
Conclusion:
The present study suggests that IL-6 level increases and SOD level decreases with severity of peri-implant diseases.
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