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Updated: May 9, 2025

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Advances in cell-penetrating peptide-based nose-to-brain drug delivery systems
Shuai Hong1, Jinyou Piao1, Junsheng Hu1
1College of Pharmacy, Yanbian University, Yanji 133002 Jilin, China.
Abstract:
The incidence of brain disorders has gained worldwide attention and the presence of the blood-brain barrier prevents numerous drugs from reaching the targeted brain. The specific physiology of the nasal cavity and the brain provides the feasibility of direct nose-brain delivery, a system that bypasses the blood-brain barrier in a non-invasive manner for brain-targeted drug delivery via intracellular and extracellular mechanisms. The use of CPPs provides further feasibility for naso-brain drug delivery studies, and liposomes, nanopolymer particles, and gels modified with CPPs have demonstrated significant brain-targeting capabilities after nasal delivery. In this paper, the physiology of the nasal cavity and brain, the pathways of naso-brain delivery and the influencing factors are discussed in detail. At the same time, the introduction, classification, mechanism of action and application of CPPs in the nasal-brain delivery system are discussed in detail to provide a theoretical basis for the in-depth study of the application of CPPs in the nasal-brain delivery system.
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