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Brain Imaging

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Related Experiment Video

Updated: May 9, 2025

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Published on: October 4, 2016

Treating Depression With Repetitive Transcranial Magnetic Stimulation: A Clinician's Guide.

Leo Chen¹, Andrew M Fukuda¹, Shixie Jiang¹

¹Department of Psychiatry, School of Translational Medicine, Monash University and Alfred Mental and Addiction Health, Alfred Health, Melbourne, Victoria, Australia (Chen); Psychiatric Neurotherapeutics Program, Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA and Department of Psychiatry, Harvard Medical School, Boston (Fukuda); Department of Psychiatry, University of Florida, Gainesville (Jiang); TMS Clinical and Research Program, Neuromodulation Division, UCLA Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles (Leuchter); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (van Rooij, McDonald); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Butler Hospital, Department of Psychiatry and Human Behavior, Alpert Medical School at Brown University, Providence, Rhode Island (Carpenter).

The American Journal of Psychiatry

|April 30, 2025

Summary

This summary is machine-generated.

Repetitive transcranial magnetic stimulation (rTMS) offers a safe and effective treatment for treatment-resistant depression (TRD). This review covers rTMS principles, clinical applications, and emerging innovations like theta burst stimulation.

Keywords:

Depressive Disorders Neurostimulation TMS

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Area of Science:

Neuroscience
Psychiatry
Biomedical Engineering

Background:

Repetitive transcranial magnetic stimulation (rTMS) has demonstrated antidepressant effects for nearly three decades.
Extensive research has focused on optimizing rTMS for treatment-resistant depression (TRD).

Purpose of the Study:

To provide a clinician-oriented review of transcranial magnetic stimulation (TMS) principles and applications in TRD.
To discuss advancements in TMS technology and treatment protocols.

Main Methods:

Review of fundamental TMS principles and physiological effects.
Evaluation of clinical trial data for rTMS in TRD.
Discussion of innovations including theta burst stimulation and accelerated scheduling.

Main Results:

Several rTMS protocols and devices are FDA-cleared for TRD and other disorders.
Clinical trial evidence supports the safety and efficacy of certain non-cleared rTMS protocols.
Advancements in coil design and stimulation parameters enhance therapeutic potential.

Conclusions:

rTMS is a valuable therapeutic option for TRD, with ongoing innovation.
Key clinical considerations include patient assessment, safety, and adverse effect management.
Emerging techniques like theta burst stimulation and accelerated scheduling show promise for wider clinical application.