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Activity of rezafungin against Candida auris
Jeffrey B Locke1, David Andes2, Shawn Flanagan1
1Cidara Therapeutics, Inc., San Diego, CA, USA.
The Journal of Antimicrobial Chemotherapy
|April 30, 2025
Summary
Rezafungin shows promising antifungal activity against Candida auris, a multidrug-resistant pathogen causing invasive infections. Further clinical studies are needed to confirm its effectiveness in treating candidemia and invasive candidiasis.
Area of Science:
- Infectious Diseases
- Mycology
- Antimicrobial Resistance
Background:
- Candida auris causes increasingly prevalent, multidrug-resistant candidemia and invasive candidiasis with high mortality.
- Existing treatments are challenged by resistance, necessitating novel therapeutic options.
Purpose of the Study:
- To review available evidence on rezafungin's activity and effectiveness against Candida auris.
- To evaluate rezafungin as a potential treatment for C. auris infections.
Main Methods:
- Literature review of in vitro, in vivo non-clinical experiments, and pharmacokinetic/pharmacodynamic analyses.
- Assessment of rezafungin's potency and spectrum of activity against Candida species.
Main Results:
- Rezafungin exhibits in vitro and in vivo antifungal activity against C. auris, comparable or superior to other echinocandins.
- Activity is maintained against wild-type and some resistant isolates but reduced in fks-mutant strains.
- Pharmacokinetic data suggest favorable dosing and exposure profiles.
Conclusions:
- Rezafungin demonstrates potential as a viable treatment option for candidemia and invasive candidiasis caused by C. auris.
- Limited clinical data necessitate further investigation to establish therapeutic efficacy.
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