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High-Resolution Sequencing Identifies Six Novel HLA-DRB1 Alleles

Maria Loginova1,2, Daria Smirnova1, Igor Paramonov1

  • 1Federal State Budget Research Institution: Kirov Hematology and Blood Transfusion Research Institute Under the Federal Medicine and Biology Agency, Kirov, Russia.

HLA
|April 30, 2025
PubMed

Keywords:
HLA‐DRB1NGSbone marrow donornovel allele

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...