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Articles linked to this work by shared authors, journal, and citation graph.

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Identification and Characterization of CAPA Receptor in Western Flower Thrips: Specific Insights Into CAPA Signaling by Naturally Occurring Peptides and CAPA-Derived Peptide Analogs.

Archives of insect biochemistry and physiology·2025
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Bioactive peptides inhibit feeding activity in the grey garden slug, Deroceras reticulatum.

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Functional expression and characterization of CAPA receptor in the digestive tract and life stages of Drosophila suzukii, and differential activities with insect PRXamide peptides.

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The functional assay identified authentic interactions between CAPA peptides and the CAPA receptor isoforms in Bemisia tabaci (Gennadius).

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CAPA Neuropeptide and Its Receptor in Insects: A Mini Review.

Sudeshna Thakur1, Vikas Jindal1, Man-Yeon Choi2

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|April 30, 2025
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Summary

The CAPA peptide-receptor system regulates insect fluid balance and physiological processes. Understanding this interaction is key for developing novel pest management strategies targeting insect excretion.

Keywords:
CAPACAPA receptorGPCRantidiuresisdiuresisneuropeptide

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Area of Science:

  • Insect physiology
  • Neuroendocrinology
  • G protein-coupled receptors (GPCRs)

Background:

  • CAPA (Crustacean Allatotropin-Associated) peptides and their receptors (CAPA-R) are crucial signaling molecules in insects.
  • CAPA-R, a type of GPCR, mediates diverse physiological functions including ion-water homeostasis.
  • These peptides are synthesized in the abdominal neurohemal system and activate CAPA-R.

Purpose of the Study:

  • To provide a comprehensive review of insect diuresis/antidiuresis mechanisms.
  • To highlight the role of CAPA peptide-receptor interactions in insect physiology.
  • To explore the potential of targeting CAPA-R for pest management.

Main Methods:

  • Literature review of existing research on CAPA peptides and their receptors in insects.
  • Analysis of physiological roles including fluid balance, stress, reproduction, and diapause.
  • Discussion of gene silencing and its implications for pest control.

Main Results:

  • CAPA-R activation primarily leads to antidiuresis and ion-water homeostasis in most insects.
  • Diverse physiological roles of CAPA peptides include fluid and energy balance, stress tolerance, muscle function, reproduction, and diapause.
  • CAPA peptides are important targets for medical and agricultural entomology.

Conclusions:

  • The CAPA peptide-receptor system is central to insect physiological regulation.
  • Targeting CAPA-R offers a promising avenue for developing new pest management strategies.
  • Understanding insect excretion is vital for effective capa-r gene silencing and integrated pest management.