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Identification of the Novel Allele HLA-DPB1*1782:01 in a Deceased Donor by Third-Generation Sequencing

S Johnson1, A Carriker2, J Grojean3

  • 1Histocompatibility & Immunogenetics Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, Illinois, USA.

HLA
|April 30, 2025
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...