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Updated: May 9, 2025

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
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Approaches to Imaging Immune Activation Using PET

Ashwin Singh Parihar1, Niharika Pant2, Pedram Heidari3

  • 1Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|April 30, 2025
PubMed

This review explores the role of PET in imaging immune activation, particularly in oncology. 18F-FDG is widely used for assessing treatment response to immunotherapies and can demonstrate unique response patterns as well as immune-related adverse events. However, because of the limited specificity of 18F-FDG, newer PET radiopharmaceuticals targeting specific cellular or subcellular components of the immune system have been developed that can provide more precise information. The development of immune-specific PET radiopharmaceuticals offers significant potential for improving immune monitoring in both clinical practice and research.

Keywords:
FDGPETimmune-related adverse eventsimmunotherapytumor microenvironment

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