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Related Experiment Video

Updated: May 9, 2025

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Comparative study of microneedle insertion across different skin models.

Xuan He1, Xue Sui1, Yongchao Liu1

  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Computer Methods in Biomechanics and Biomedical Engineering
|April 30, 2025
PubMed
Summary

Microneedle (MN) hardness is key for safe skin insertion. This study used finite element methods (FEM) to compare MN performance across different skin models, aiding optimal model selection and MN design.

Keywords:
Microneedles (MNs)finite element method (FEM)simulation analysistransdermal drug delivery

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Computational Modeling

Background:

  • Microneedles (MNs) offer painless drug delivery by piercing the stratum corneum.
  • MN hardness is critical for safe and effective skin insertion.
  • Variability in human/animal skin and synthetic models, plus limitations in finite element methods (FEM) simulations, hinder consistent MN performance evaluation.

Purpose of the Study:

  • To compare microneedle (MN) performance across various skin models using finite element methods (FEM) under uniform conditions.
  • To identify the most suitable skin models for MN testing.
  • To provide insights for optimizing species-specific MN design.

Main Methods:

  • Utilized finite element methods (FEM) for computational simulation of MN insertion.
  • Compared MN performance across diverse skin models, including human and animal tissues, and synthetic materials.
  • Ensured uniform simulation conditions for direct comparison of MN behavior.

Main Results:

  • Observed minimal differences in volume change during MN insertion across models.
  • Established a ranking of penetration ease for different human and animal skin models.
  • Demonstrated the utility of FEM in standardizing MN performance assessment.

Conclusions:

  • FEM provides a consistent framework for evaluating MN insertion across various skin models.
  • The findings facilitate informed selection of appropriate skin models for MN research.
  • This approach supports the optimization of MN design for targeted drug delivery applications across species.