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Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Baseline characterisation of adults living with spinal muscular atrophy in the UK: insight from the Adult SMA REACH Real-World Data Collection Study.

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Modifying disease registries to address the evolving field in rare diseases: the iSMAc/ITASMAc experience in spinal muscular atrophy.

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Related Experiment Video

Updated: May 9, 2025

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

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Published on: November 8, 2024

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Serial casting for contractures in SMA: consensus derived guidelines for treatment.

Laurey Brown1, Katie Hoffman1, Chiara Corbo-Galli2

  • 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.

Frontiers in Neurology
|May 1, 2025
PubMed
Summary

Serial casting guidelines were developed for Spinal Muscular Atrophy (SMA) patients to improve flexibility and function. These consensus-based recommendations aim to standardize care for individuals with SMA, addressing contractures and range of motion limitations.

Keywords:
Delphi techniqueconsensuscontractureserial castingspinal muscular atrophy

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Area of Science:

  • Physical Therapy
  • Rehabilitation Medicine
  • Neuromuscular Disorders

Background:

  • Spinal Muscular Atrophy (SMA) frequently leads to muscle contractures, impacting joint mobility.
  • Serial casting is a recognized intervention for improving range of motion in various neuromuscular conditions.

Purpose of the Study:

  • To establish a consensus on best practices for serial casting in individuals with SMA.
  • To develop guidelines for optimizing flexibility and functional outcomes through serial casting in SMA patients.

Main Methods:

  • An international expert panel of physical therapists conducted multiple meetings and a 2-round Delphi survey.
  • Consensus was achieved on 296 items across clinical appropriateness, program considerations, and adherence/feasibility.
  • Patient and caregiver insights were gathered through semi-structured interviews.

Main Results:

  • Strong consensus (>75% validity index) was reached across all three domains.
  • High agreement rates were observed: 96.6% for clinical appropriateness, 95.0% for program considerations, and 96.9% for adherence/feasibility.
  • A comprehensive guideline document was created based on expert consensus and community feedback.

Conclusions:

  • Developed serial casting guidelines should be implemented for patients with Spinal Muscular Atrophy.
  • Further research is needed to validate the efficacy of these guidelines in improving joint contractures and function in SMA.